9 effects of sr9009 (stenabolic)

Conclusion

Let’s get real for a second and look at all the facts.

Beyond the glitz and glamor of all of Stenabolic’s claims, this ‘non’ SARM is illegal, has been banned by the WADA AND has yet to be tested on people.

Sure all of the clinical studies on mice may point towards it being able to: build up lean muscle mass, prevent muscle wasting, boost fat loss and improve your sleep, metabolism and physical performance – without causing side effects. However, until these claims can be substantiated based on studies on real people, then you can only take it with a pinch of salt.

After all, why put your body at risk when you don’t have to?

Products such as CrazyBulk’s TestoMax for example have been uniquely formulated from numerous natural testosterone boosters – boron, magnesium, Fenugreek, zinc, Vitamins D, B6 and F1 (to name a few) – because of their ability to increase lean muscle mass, cut fat, improve muscle recovery and maximize your endurance, stamina and strength. In fact, TestoMax can offer you the EXACT same results as other leading SARMs and can do so 100% naturally, safely and legally!

So if you’re interested in achieving real lasting lean muscle gains, we strongly recommend going the natural route instead. SR 9009 may look perfect on the outside, but there is still too much we don’t know about this product and what it can actually do.

Researched Effects

1) Weight Loss

Mice injected with SR9009 for 7 days lost weight due to a decrease in fat mass. Food intake was not affected [].

Similarly, diet-induced obese mice injected with SR9009 for 30 days lost 60% more weight than control animals. Blood levels of triglycerides, total cholesterol, free fatty acids, and insulin levels also decreased [].

In genetically obese mice, SR9009 stopped weight gain after 12 days without affecting glucose levels or insulin tolerance [].

2) Blood Cholesterol

SR9009 given for 7 to 10 days reduced blood levels of triglycerides and total cholesterol in mice [].

Genetically modified mice undergoing a high cholesterol diet to obtain a fat profile similar to humans were given SR9009 for 8 weeks. Total cholesterol and triglycerides were similarly lowered, while LDL cholesterol was lowered but HDL cholesterol was unaffected [].

3) Endurance

Mice treated with SR9009 for 30 days showed increased endurance. They ran for a longer time and covered more distance than controls [].

SR9009 increased the number of total and active mitochondria in muscle cells (by repressing autophagy genes) [].

4) Decreasing Inflammation

SR9009 diminished lung inflammation in rats (by reducing the production of TNF-alpha) [].

It also reduced the production of inflammatory molecules (CCL2, MMP-9) in rat nerve cells [].

5) Heart Disease

Genetically modified mice susceptible to hardening of the arteries were treated with SR9009 for 7 weeks. The size of the blood vessel lesions was reduced, while food intake, body weight, and blood fat levels were not affected [].

In both normal and genetically modified old mice, SR9009 injected for 28 days improved heart function [].

In mice with surgically induced heart growth (hypertrophy), SR9009 given for 2 weeks reduced heart size and weight, with no effect on blood pressure [].

6) Wakefulness

As an activator of REV-ERB, S9009 changes sleep/wake patterns in mice. However, its effects are short-term and last only 12 hours .

Mice injected with SR9009 during daytime (this is when the mice are supposed to be asleep) were more active during the day and had less deep sleep (less REM and slow-wave sleep). However, when SR9009 was injected during the night (when mice are active), it had no effect .

SR9009 may potentially help in maintaining wakefulness when the drive for sleep is significant including shift work, jet lag, and some sleep-related disorders.

7) Anxiety

SR9009 injected twice a day for 3 to 10 days, decreased anxiety-like behavior in mice and was as effective as a benzodiazepine [].

8) Tissue Damage (Fibrosis)

How to use Stenabolic – Dosages

In order to give a proper Stenabolic review, we need to consider dosages.

Now given that SR 9009 has only got a half-life of 4 hours, this means it will instantly be absorbed into your system. As a result, you’ll need to take into account your goals before you decide upon whether to take it as a single dose or spaced out across the day.

Scenario One: if your goal is to and lift weights, then users recommend taking Stenabolic an hour before exercise to keep you alert and energized.

Scenario Two: if you’re looking to get more sleep and be at your mental best, then it is recommended that you take it throughout the day (three doses of 10mg each).

In either case, the most you should ever take is 50mg a day. This is the upper limit you can safely use before seeing any potential side effects. To better safeguard your body though, most users recommend starting out small with just 5mg a day, before progressing to 30mg (split over three doses). This will help you to build up a tolerance and minimize any sleep related problems.

More importantly, 30mg a day will keep you on top of your game – and energized – as well as will help you to achieve decent fat loss and muscle mass gains.

What about cycles?

A typical Stenabolic cycle should only last 8 weeks.

How does Stenabolic SR 9009 work?

We touched on this briefly in the section above; however, to help give you a better idea here is what we know:

Our bodies work in 24-hour cycles known as the circadian rhythm. This pattern is maintained by utilizing a loop mechanism which turns your genes on and off e.g. when CLOCK and BMAL1 genes are turned on, this turns on PER and CRY. When they turn on, CLOCK and BMAL1 get turned off. The process then resets.

Now REV-ERBs are a pair of proteins that are designed to stabilize this internal clock by turning off BMAL1. In turn, these proteins are activated by the heme group (a small iron-containing compound e.g. red blood cells).

As you can guess, when you add SR 9009 into the equation, it enhances this REV-ERB activity (NOTE: REV-ERB is found in your liver, muscles and fat tissues) and triggers the following:

  • Liver – REV-ERB affects the rhythm of 90% of the genes under circadian control in your liver (well, in the livers of mice anyway). It turns off the genes which produce glucose, whilst turning on the genes responsible for generating new fat cells. At the same time, it reduces your inflammatory response.
  • Fat cells – REV-ERB turns off the genes involved in fat storage helping to decrease triglyceride production.
  • Muscles – REV-ERB encourages fat burn whilst also increasing mitochondria activity (by encouraging the creation of new mitochondria, as well as reducing the destruction of old mitochondria).

In animal and cell studies, SR-9009 was found to: increase oxygen consumption; decrease the production of new fat cells, cholesterol and bile acids in the liver; increase the presence of mitochondria, glucose and fatty acid use in muscles, and reduce fat storage.

FACT: There is more to gaining lean muscle than lifting weights. At the core of anabolism is endurance, strength, sleep and recovery.

  • Endurance, energy and stamina – if you don’t have these, then you won’t be able to lift as much/or as hard as you want to.
  • Sleep – if you’re sleep deprived, then natural testosterone production and secretion of growth hormones will drop.
  • Recovery – if your body doesn’t have the time or the resources to recover fully from physical stress, then you will end up with sore muscles or worse torn ligaments.

Stenabolic can prime your body, keep you focused (for up to 12 hours due to its short half-life) and ensure you sleep like a rock, so you are more than capable of handling even the heaviest workout.

More importantly, it can improve your cardiac health and fat burn (even when you’re at rest), helping you to achieve chiseled, rock hard abs and clear definition.

Benefits of SR-9009 – our Stenabolic review

Still with us so far? Great!

We admit the science behind this product can be a little overwhelming, but once you get past all the jargon, what you are left with is an oral supplement that could transform your bodybuilding endeavors.

With SR-9009 you can expect to experience the following benefits:

    1. Increased fat burn – by switching off the genes responsible for glucose production (without wreaking havoc on your body’s insulin sensitivity), this forces your body to use stored fat for energy expenditure, resulting in greater fat loss. At the same time, by amplifying mitochondria production this helps to boost your metabolism, so even in a state of rest/sleep, you will burn fat.When diet-induced mice were injected with SR-9009 for 30 days, they lost 60% more weight than those on the placebo. Whilst, genetically obese mice in a separate study stopped gaining weight after 12 days (without their glucose levels being affected).
    1. Lean muscle – by swapping out old mitochondria for new, SR 9009 can boost the rate at which you produce new muscle. This can be further enhanced by stacking it with SARMs such Ligandrol, as together they can help you to pack on muscle in a short space of time.
    1. Reduced cholesterol, triglyceride and LDL levels – Stenabolic can help control LDL levels whilst helping to raise HDL levels. When mice were given SR-9009 for 7-10 days, their triglyceride and total cholesterol blood levels dropped.
    1. Circadian Rhythm – SR 9009 can help keep you active and alert for up to 12 hours a day, which is great news for your workout regime, as it can help combat feelings of fatigue during hard-core sessions.
    1. Faster recovery – by keeping your mitochondria levels fresh and new (by phasing out and replacing old/dead mitochondria cells), this can boost your recovery rate after exercise. In studies on mice, SR-9009 reduced inflammation and tissue damage.
    1. Endurance – SR 9009 can help raise your endurance levels enabling you to workout harder without you crashing. For instance, if you were to reach your maximum heart rate within 30 minutes of HIIT, then Stenabolic will enable you to do the same HITT at just 75% of your heart rate, enabling you to go a further 10 minutes before you hit your max.In a study of mice given SR 9009 for 30 days, they saw a notable increase in endurance and were able to run for longer/cover more distance.
    2. Sleep – alongside being able to keep you active all day long; Stenabolic can also help you to experience a restful, uninterrupted night’s sleep.
  1. Anxiety – injected twice a day for 3-10 days, mice exhibited reduced anxiety-like behavior.

Is SR-9009 safe?

On the one hand, we could say yes. To date, there have been no SR 9009 side effects when it was taken at the recommended dosage for short cycles. However, here is the thing – Stenabolic has NEVER been tested on humans. NEVER.

All of those benefits and clinical trials we mentioned above? Well, they were done on mice, meaning the safety of SR 9009 on people cannot be 100% guaranteed.

What is actually needed is more research – on people – to fully determine both its benefits and potential side effects.

So far though:

  • There have been no signs of liver toxicity
  • 15-20% of users have reported suffering from insomnia (ironic we know, given that it is meant to encourage a good night’s sleep, not the opposite), which disappeared once they lowered their dose or stopped using it.

What is Stenabolic SR 9009?

Stenabolic (or SR-9009 for short) is often mistaken for a SARM but it is actually a synthetic drug (REV-ERB) that was originally created to help study circadian rhythm.

All too often athletes forget about the impact strenuous exercise and physical stress can have on the mind. From a lack of alertness and brain-fog to a loss in concentration; this lack of focus can hinder your performance in the gym.

And this makes sense when you think about it…

Lack of concentration will lead to a lack of willpower, which in turn will lead to you failing to hit that extra rep. How can you keep track of your sets when your brain is out of whack?

Luckily, SR 9009 can help you to turn the tables…

Alongside being able to: boost endurance and recovery; reduce anxiety; decrease cholesterol, weight and inflammation, and increase lean muscle mass; Stenabolic can also help stabilize circadian rhythm allowing you to focus, remain alert and concentrate whilst exercising.

The Science:

As a REV-ERB agonist, Stenabolic can enhance/amplify the activity of REV-ERB proteins, which are responsible for controlling an array of functions within your body – including energy expenditure. By changing gene expression and turning off glucose production – without interfering with insulin sensitivity – SR 9009 is able to utilize fat for energy, whilst also helping to reduce your cholesterol levels.

In addition, by altering your circadian rhythm, this is believed to trigger a series of activities in your liver, skeletal muscle and adipose tissue which can bolster the production rate of mitochondrial cells.

In one study on obese mice (published in the Journal of Natural Medicine), SR-9009 helped them to become more active; utilized their fat stores for energy; bolstered fat loss, and helped them to gain additional lean muscle mass. At the same time, they were able to run for longer – and over a greater distance – as they were more alert and focused.

But that is not all it can do…

SR 9009 has also got a long history of being able to prevent muscle wasting in those with Sarcopenia. Meaning it could potentially help you to protect all of those lean muscle mass and strength gains without triggering side effects (like most anabolic androgenic steroids).

Yet, there is a catch…

Not only has it been banned by the WADA – and been categorized as an S4 (a hormone and metabolic modulator) – Stenabolic has never been tested on humans. So whilst many sites might claim that SR 9009 won’t trigger side effects. The truth is – there is no proof saying it won’t. It is all speculation.

Is it something you should buy?

If we’re completely honest – no it isn’t. Not only is it illegal and has been banned by the WADA; Stenabolic has NEVER been tested on humans. NEVER. All current research has been done on mice, who let’s face it aren’t exactly biologically identical to us.

This means all of its claims to burn fat, help you sleep and encourage new muscle growth are a little unfounded.

Then, of course, there is the fact that many of the SR 9009 products you’ll find online are not the real deal, but are fake imitations created from poor quality ingredients (thanks, but no thanks).

S23 SARM – Benefits, Dosage and Side Effects >>

Precautions

Side Effects

The side effects of SR9009 are unknown. This drug has serious potential for harm. Taking would be extremely dangerous since its safety profile has not been investigated.

So far, SR9009 has shown no liver toxicity in mice when used for up to 7 weeks [].

Some users reported insomnia.

Dosage

No human dosage has been established so far. Most experiments in mice have used a dose of 100 mg/kg applied intraperitoneally; that is, injected directly into the body cavity.

Online bodybuilding forums, however, suggest a much lower daily dose of 10-40 mg. They also suggest dividing this into 3-4 doses per day.

There are no scientific reports on the effectiveness of SR9009 when taken orally.

User Experiences

SR9009 is sold online for use as a performance enhancer in bodybuilding.

Some users report improved endurance, while others state it has limited or no benefits. For many, the suggested repeated dosing (3-4 times a day) makes it bothersome to use.

  • “I feel it immediately. With SR9009 it’s like there’s this little “pop” of alertness. It can cause insomnia (which happened to me), and might explain that “pop” like a flash of “it’s daytime!”
  • “I’ve used it a bit. The energy and stamina increases are pretty pronounced.”
  • “It gives really nice increases to endurance, but feels different than a traditional stimulant.”
  • “Didn’t feel much.”

About SR9009 (Stenabolic)

What is it exactly?

Stenabolic or SR9009 is a research chemical. To date, no human studies on the use of SR9009 have been published. 

Thus, we don’t know how dangerous this substance may be. Its effectiveness in humans is also unknown. This means it has a high potential for harm and should be avoided at all costs.

Taken from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090048/

Our bodies function in a coordinated manner, in 24-hour cycles that are adjusted to the rise and fall of the sun. This pattern is called the circadian rhythm.

The circadian rhythm is maintained through a loop mechanism that turns genes on and off (when CLOCK and BMAL1 genes are turned on, they turn on PER and CRY. Then, PER/CRY turn BMAL1/CLOCK off and the 24-hour cycle resets) [].

The REV-ERBs are a pair of proteins that stabilize our internal clock by turning BMAL1 off. They are, in turn, activated by the heme group. Heme is a small iron-containing compound found all throughout our body, for example, in red blood cells .

SR9009 is a compound that enhances REV-ERB activity (known as agonists) and has good bioavailability [].

Because of the many positive effects seen in animals, SR9009 found its way online and is being sold and used as a supplement, mainly within the bodybuilding community. It has been referred to as “exercise in a bottle.” However, there are still a lot of things we don’t know about this drug, including its side effects.

Mechanism of Action

All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production .

REV-ERB is mainly found in liver, muscle, and fat tissue:

  • Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) .
  • Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [].
  • Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [].

In animal and cell studies, SR9009:

  • Increased oxygen consumption []
  • Decreased generation of new fat cells in the liver []
  • Decreased production of cholesterol and bile acids in the liver []
  • Increased the number of mitochondria in muscle []
  • Increased glucose and fatty acid use in muscle []
  • Decreased fat storage []
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